Publications

Publication list

2022

  1. Aberle T, Piefke S, Hillgärtner S, Tamm ER, Wegner M, Küspert M (2022) Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Nucleic Acids Research 50, S. 1951-1968
  2. Battis K, Florio J B, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller S J, Cobo I, Fixsen B, Kim H Y, Masliah E, Glass C, Schlachetzki J C M, Rissman R, Winkler J, Hoffmann, A. (2022). CSF1R-mediated myeloid cell depletion prolongs lifespan but aggravates distinct motor symptoms in a model of multiple system atrophy. Journal of Neuroscience. 42(40). 7673-7688.
  3. Karpf J, Unichenko P, Chalmers N, Beyer F, Wittmann MT, Schneider J, Fidan E, Reis A, Beckervordersandforth J, Brandner S, Liebner S, Falk S, Sagner A, Henneberger C, Beckervordersandforth R (2022) Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nature Neuroscience, 2022 (in press). doi10.1038/s41593-022-01192-5
  4. Schneider J, Weigel J, Wittmann MT, Svehla P, Ehrt S, Zheng F, Elmzzahi T, Karpf J, Panagua-Herranz L, Basak O, Ekici A, Reis A, Alzheimer C, Ortega F, Liebscher S, Beckervordersandforth R (2022) Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. The EMBO Journal doi.org/10.15252/embj.2021110409
  5. Lanfer J, Kaindl J, Krumm L, Gonzalez Acera M, Neurath M, Regensburger M, Krach F, Winner B. Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells. International Journal of Molecular Sciences. 2022; 23(9):4526
  6. Regensburger M, Krumm L, Schmidt MA, Schmid A, Spatz IT, Marterstock DC, Kopp C, Kohl Z, Doerfler A, Karrasch T, Winner B, Winkler J. Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia. Nutrients. 2022; 14(22):4803
  7. Leupold L, Sigutova V, Gerasimova E, Regensburger M, Zundler S, Zunke F, Xiang W, Winner B, Prots I. The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis. Front Neurol. 2022;13:869103. PMCID: PMC9334871
  8. Utz KS, Kohl Z, Marterstock DC, Doerfler A, Winkler J, Schmidt M, Regensburger M. Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia. Orphanet J Rare Dis. 2022 Jul 18;17(1):301. PMCID: PMC9336101
  9. Regensburger M, Spatz IT, Ollenschläger M, Martindale CF, Lindeburg P, Kohl Z, Eskofier B, Klucken J, Schüle R, Klebe S, Winkler J, Gaßner H. Inertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia. Neurology. 2022;99(10):e1079–e1089. PMCID: PMC9519248
  10. Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ, Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J, Yeo GW, Winner B. Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathol. 2022;144(3):413–435. PMCID: PMC9381448
  11. Regensburger M, Chaudhry SR, Yasin H, Zhao Y, Stadlbauer A, Buchfelder M, Kinfe T. Emerging roles of leptin in Parkinson’s disease: chronic inflammation, neuroprotection and more? Brain Behav Immun. 2022;107:53–61. PMID: 36150585
  12. Julia Kicherer, Alicia Weier, Michael Enders, Winfried Neuhuber, Thorsten Heider and Stefanie Kuerten (2022) Characterization of Neurochemical Signature Alterations in the Enteric Nervous System in Autoimmune Encephalomyelitis Appl. Sci.
  13. Felix Boltz, Michael Enders, Andreas Feigenspan, Philipp Kirchner, Arif Ekici and Stefanie Kuerten (2022) Nimodipine Exerts Beneficial Effects on the Rat Oligodendrocyte Cell Line OLN-93 Brain Sci.
  14. Rittika Chunder, Alicia Weier, Hannah Mäurer, Nicolas Luber, Michael Enders, Gabriele Luber, Thorsten Heider, Alfred Spitzer, Sabine Tacke, Janine Becker-Gotot, Christian Kurts, Radhika Iyer, Peggy P Ho, William H Robinson, Tobias V Lanz, Stefanie Kuerten (2022) Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination Natl. Acad. Sci.
  15. Alicia Weier, Michael Enders, Philipp Kirchner, Arif Ekici, Marc Bigaud, Christopher Kapitza, Jürgen Wörl and Stefanie Kuerten Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis J. Mol. Sci.
  16. Schneider, Y., Wihan, J., Turan, S., Winkler, J. (2022). Cell-Based Therapy and Genome Editing in Parkinson’s Disease: Quo Vadis?. In: Dederer, HG., Hamburger, D. (eds) Brain Organoids in Research and Therapy. Advances in Neuroethics. Springer, Cham.
  17. Yanni Schneider, Soeren Turan, Aron Koller, Mandy Krumbiegel, Michaela Farrell, Sonja Plötz, Jürgen Winkler, Wei Xiang (2022) Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression Stem Cell Research
  18. Seebauer, L.; Schneider, Y.; Drobny, A.; Plötz, S.; Koudelka, T.; Tholey, A.; Prots, I.; Winner, B.; Zunke, F.; Winkler, J.; Xiang, W. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson’s Patient-Derived Neuronal Cells. J. Mol. Sci. 2022, 23, 1812.

2021

  1. Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A (2021) Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation. Cell Mol Life Sci. doi: 10.1007/s00018-021-03835-5.
  2. González-Alvarado MN, Aprato J, Baumeister M, Lippert M, Ekici AB, Kirchner P, Welz T, Hoffmann A, Winkler J, Wegner M, Haase S, Linker RA (2021) Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation. Glia. doi: 10.1002/glia.24120.
  3. Güner F, Pozner T, Krach F, Prots I, Loskarn L, Schlötzer-Schrehardt U, Winkler J, Winner B, Regensburger M (2021) Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Front. Neurosci. 15:680572. doi: 10.3389/fnins.2021.680572.
  4. Ittner E, Hartwig AC, Elsesser O, Wüst HM, Fröb F, Wedel M, Schimmel M, Tamm ER, Wegner M, Sock E (2021) SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system. Sci Rep 11, 14044. doi: 10.1038/s41598-021-93437-9.
  5. Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP (2021) Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. Mol Psychiatry. doi: 10.1038/s41380-021-01304-w
  6. Kapitza C, Chunder R, Scheller A, Given KS, Macklin WB, Enders M, Kuerten S, Neuhuber WL, Wörl J (2021) Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. Int J Mol Sci. 22(6):3233. doi: 10.3390/ijms22063233.
  7. Koeniger T, Bell L, Mifka A, Enders M, Hautmann V, Mekala SR, Kirchner P, Ekici AB, Schulz C, Wörsdörfer P, Mencl S, Kleinschnitz C, Ergün S, Kuerten S (2021) Bone marrow-derived myeloid progenitors in the leptomeninges of adult mice. Stem Cells. 39(2):227-239. doi: 10.1002/stem.3311.
  8. Krumm L, Pozner T, Kaindl J, Regensburger M, Günther C, Turan S, Asadollahi R, Rauch A, Winner B (2021) Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. Stem Cell Res. 56:102520. doi: 10.1016/j.scr.2021.102520.
  9. Lin CH, Kornhuber J, Zheng F, Alzheimer C (2021) Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability. Front Cell Neurosci. 15:660561. doi: 10.3389/fncel.2021.660561.
  10. Mészáros L, Riemenschneider MJ, Gassner H, Marxreiter F, von Hörsten S, Hoffmann A, Winkler J (2021) Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 9(1):68. doi: 10.1186/s40478-021-01166-x.
  11. Reyes JF, Ekmark-Léwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M (2021) Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease. Acta Neuropathol Commun.;9(1):46. doi: 10.1186/s40478-021-01136-3.
  12. Ryl M, Urbasik A, Gierke K, Babai N, Joachimsthaler A, Feigenspan A, Frischknecht R, Stallwitz N, Fejtová A, Kremers J, von Wittgenstein J, Brandstätter JH (2021) Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes. FASEB J. 35(5):e21520. doi: 10.1096/fj.202001962R.
  13. Schulze-Krebs A, Canneva F, Stemick J, Plank A-C, Harrer J, Bates GP, Aeschlimann D, Steffan JS, von Hörsten S (2021) Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models. International Journal of Molecular Sciences.  22(16):8914. doi: 10.3390/ijms22168914.
  14. Wittmann MT, Katada S, Sock E, Kirchner P, Ekici AB, Wegner M, Nakashima K, Lie DC, Reis A (2021) scRNA-Sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development. Development. dev.196022. doi: 10.1242/dev.196022.

2020

  1. Aprato J, Sock E, Weider M, Elsesser O, Fröb F, Wegner M (2020) Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development. Nucleic Acids Res 48: 1254-1270. doi: 10.1093/nar/gkz1158
  2. Boerstler T, Wend H, Krumbiegel M, Kavyanifar A, Reis A, Lie DC, Winner B, Turan S (2020) CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome. Stem Cell Res 47: 101889. doi: 10.1016/j.scr.2020.101889
  3. Braun K, Häberle BM, Wittmann MT, Lie CD (2020) Environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. BMC Neurosci. 2020 Nov 23;21(1):50. doi: 10.1186/s12868-020-00602-3.
  4. Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039
  5. Cerrone F, Pozner T, Siddiqui A, Ceppi P, Winner B, Rajendiran M, Babu R, Ibrahim HS, Rodriguez BJ, Winkler J, Murphy KJ, O’Connor KE (2020) Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells. Mater Sci Eng C Mater Biol Appl 111: 110832. doi: 10.1016/j.msec.2020.110832
  6. Enders M, Heider T, Ludwig A, Kuerten S (2020) Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium. Int J Mol Sci 21(5). pii: E1663. doi: 10.3390/ijms21051663
  7. Endres D, Pruss H, Rauer S, Süß P, Venhoff N, Feige B, Schweizer T, Nickel K, Maier S, Egger K, Domschke K, Meyer PT, Tebartz van Elst L (2020) Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings. Biol Psychiatry 87: e29-e31. doi: 10.1016/j.biopsych.2019.12.020
  8. Endres D, Rauer S, Pschibul A, Süß P, Venhoff N, Runge K, Feige B, Denzel D, Nickel K, Schweizer T, Maier S, Egger K, Domschke K, Meyer PT, Prüss H, Tebartz van Elst L (2020) Novel Antineuronal Autoantibodies With Somatodendritic Staining Pattern in a Patient With Autoimmune Psychosis. Front Psychiatry 11:627.doi: 10.3389/fpsyt.2020.00627.
  9. Fliedner A, Gregor A, Ferrazzi F, Ekici AB, Sticht H, Zweier C (2020) Loss of PHF6 leads to aberrant development of human neuron-like cells. Sci Rep 2020 Nov 4;10(1):19030. doi: 10.1038/s41598-020-75999-2.
  10. Fliedner A, Kirchner P, Wiesener A, van de Beek I, Waisfisz Q, van Haelst M, Scott DA, Lalani SR, Rosenfeld JA, Azamian MS, Xia F, Dutra-Clarke M, Martinez-Agosto JA, Lee H, Center UCG, Noh GJ, Lippa N, Alkelai A, Aggarwal V, Agre KE, Gavrilova R, Mirzaa GM, Straussberg R, Cohen R, Horist B, Krishnamurthy V, McWalter K, Juusola J, Davis-Keppen L, Ohden L, van Slegtenhorst M, de Man SA, Ekici AB, Gregor A, van de Laar I, Zweier C (2020) Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing. Am J Hum Genet. doi: 10.1016/j.ajhg.2020.06.019
  11. Frankowska M*, Jesus FM*, Mühle C*, Pacheco JVN, Maior RS, Sadakierska-Chudy A, Smaga I, Piechota M, Kalinichenko LS, Gulbins E, Kornhuber J, Filip M*, Müller CP*, Barros M* (2020) Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior-A translational study in rats and monkeys. Addict Biol: e12955. doi: 10.1111/adb.12955
  12. Gonzalez-Alvarado MN, Rötger C, Berger L, London B, Haase S, Kuhbandner K, Lee DH, Linker RA (2020) Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol 343: 577227. doi: 10.1016/j.jneuroim.2020.577227
  13. Heppt J, Wittmann MT, Schäffner I, Billmann C, Zhang J, Vogt-Weisenhorn D, Prakash N, Wurst W, Taketo MM, Lie DC (2020) beta-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO J:e104472.doi: 10.15252/embj.2020104472.
  14. Janke E, Groh A, Mühle C, Dürsteler-MacFarland KM, Wiesbeck GA, Kornhuber J, Jahn K, Groeschl M, Lichtinghagen R, Frieling H, Bleich S, Hillemacher T, Lenz B, Heberlein A (2020) Association of Testosterone Levels and Steroid 5-Alpha-Reductase 2 Polymorphisms with Opioid Craving. Neuropsychobiology: 1-10. doi: 10.1159/000508681
  15. Kalinichenko LS*, Abdel-Hafiz L*, Wang AL*, Mühle C*, Rosel N, Schumacher F, Kleuser B, Smaga I, Frankowska M, Filip M, Schaller G, Richter-Schmidinger T, Lenz B, Gulbins E, Kornhuber J, Oliveira AWC, Barros M, Huston JP, Müller CP (2020) Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory. Cereb Cortex. DOI: 10.1093/cercor/bhaa298
  16. Kalinichenko LS*, Wang AL*, Mühle C*, Abdel-Hafiz L, Gulbins E, Kornhuber J, Oliveira AWC, Barros M, Huston JP, Müller CP (2020) Neutral ceramidase is a marker for cognitive performance in rats and monkeys. Pharmacol Rep. DOI: 10.1007/s43440-020-00159-2
  17. Krach F, Bogiongko ME, Winner B (2020) Decoding Parkinson’s disease – iPSC-derived models in the OMICs era. Mol Cell Neurosci 106: 103501. doi: 10.1016/j.mcn.2020.103501
  18. Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8
  19. Kuzior H, Fiebich BL, Yousif NM, Saliba SW, Ziegler C, Nickel K, Maier SJ, Süß P, Runge K, Matysik M, Dersch R, Berger B, Robinson T, Venhoff N, Kessler F, Blank T, Domschke K, Tebartz van Elst L, Endres D (2020) Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression. Compr Psychiatry 102:152196.doi: 10.1016/j.comppsych.2020.152196
  20. Lambrecht V, Hanspach J, Hoffmann A, Seyler L, Mennecke A, Straub S, Marxreiter F, Bäuerle T, Laun FB, Winkler J (2020) Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2020.113314. Accepted 13 April 2020.
  21. Marxreiter F, Stemick J, Kohl Z (2020) Huntingtin Lowering Strategies. Int J Mol Sci 21(6). pii: E2146. doi: 10.3390/ijms21062146
  22. Mészáros L, Hoffmann A, Wihan J, Winkler J (2020) Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy. Int. J. Mol. Sci., 2020 Apr 16;21(8):2775. doi: 10.3390/ijms21082775.
  23. Montenegro-Venegas C*, Fienko S*, Anni D*, Pina-Fernandez E, Frischknecht R, Fejtova A (2020) Bassoon inhibits proteasome activity via interaction with PSMB4. Cell Mol Life Sci. doi: 10.1007/s00018-020-03590-z
  24. Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. 2020 May 1;awaa099. doi: 10.1093/brain/awaa099. Online ahead of print.
  25. Regensburger M (2020) Which kinds of fasciculations are missed by ultrasonography in ALS? Clin Neurophysiol 131: 237-238. doi: 10.1016/j.clinph.2019.09.011
  26. Regensburger M, Minakaki G, Kettwig M, Eisenhut F, Haack T, Kohl Z, Winkler J (2020) Novel biallelic CTSD gene variants cause late-onset ataxia and retinitis pigmentosa. Mov Disord. 2020 May 18. doi: 10.1002/mds.28106. Online ahead of print
  27. Regensburger M, Schlachetzki JCM, Klekamp J, Doerfler A, Winkler J (2020) Long-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications. BMC Neurol 20:321.doi: 10.1186/s12883-020-01891-1.
  28. Regensburger M, Stemick J, Masliah E, Kohl Z, Winner B (2020) Intracellular A53T mutant α-synuclein impairs adult hippocampal newborn neuron integration. Front Cell Dev Biol. 2020 Nov 11;8:561963. doi: 10.3389/fcell.2020.561963. eCollection 2020.
  29. Rhein C*, Mühle C*, Lenz B*, Richter-Schmidinger T, Kogias G, Boix F, Lourdusamy A, Dörfler A, Peters O, Ramirez A, Jessen F, Maier W, Hüll M, Frölich L, Teipel S, Wiltfang J, Kornhuber J, Müller CP (2020) Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. Brain Res Bull 161: 13-20. doi: 10.1016/j.brainresbull.2020.05.001
  30. Siegmann EM, Müller T, Dziadeck I, Mühle C, Lenz B*, Kornhuber J* (2020) Digit ratio (2D:4D) and transgender identity: new original data and a meta-analysis. Sci Rep. 2020 Nov 9;10(1):19326. doi: 10.1038/s41598-020-72486-6.
  31. Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, Roybon L, Prots I, Xiang W, Winner B (2020) Unique signatures of stress-induced senescent human astrocytes. Exp Neurol 334:113466.doi: 10.1016/j.expneurol.2020.113466.
  32. Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J (2020) Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson’s disease. Brain Res 1748:147119. doi: 10.1016/j.brainres.2020.147119.
  33. Straub J, Gregor A, Sauerer T, Fliedner A, Distel L, Suchy C, Ekici AB, Ferrazzi F, Zweier C (2020) Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster. Sci Rep 10: 1204. doi: 10.1038/s41598-020-58182-5
  34. Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Kronke G, Glass CK, Winkler J, Schlachetzki JCM (2020) Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep 30: 4082-4095 e6. doi: 10.1016/j.celrep.2020.02.109
  35. Süß P, Schlachetzki JCM (2020) Microglia in Alzheimer’s Disease. Curr Alzheimer Res 17(1):29-43. doi: 10.2174/1567205017666200212155234
  36. von Wittgenstein J, Zheng F, Wittmann MT, Balta EA, Ferrazzi F, Schäffner I, Häberle BM, Valero-Aracama MJ, Koehl M, Miranda CJ, Kaspar BK, Ekici AB, Reis A, Abrous DN, Alzheimer C, Lie DC (2020) Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex pii: bhz338. doi: 10.1093/cercor/bhz338
  37. von Zimmermann C, Winkelmann M, Richter-Schmidinger T, Mühle C, Kornhuber J, Lenz B (2020) Physical Activity and Body Composition Are Associated With Severity and Risk of Depression, and Serum Lipids. Front Psychiatry 11: 494. doi: 10.3389/fpsyt.2020.00494
  38. Wedel M, Fröb F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M (2020) Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res pii: gkaa218. doi: 10.1093/nar/gkaa218
  39. Weinland C, Tanovska P, Kornhuber J, Mühle C*, Lenz B* (2020) Serum lipids, leptin, and soluble leptin receptor in alcohol dependence: A cross-sectional and longitudinal study. Drug Alcohol Depend 209: 107898. doi: 10.1016/j.drugalcdep.2020.107898
  40. Wittstatt J, Weider M, Wegner M, Reiprich S (2020) MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture. Glia. doi: 10.1002/glia.23821
  41. Wüst HM, Wegener A, Fröb F, Hartwig AC, Wegwitz F, Kari V, Schimmel M, Tamm ER, Johnsen SA, Wegner M, Sock E (2020) Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination. Nucleic Acids Res. doi: 10.1093/nar/gkaa606
  42. Zeitler S, Schumacher F, Monti J, Anni D, Guhathakurta D, Kleuser B, Friedland K, Fejtová A*, Kornhuber J*, Rhein C* (2020) Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems Cells. 2020 Nov 18;9(11):2502. doi: 10.3390/cells9112502
  43. Zoicas I*, Mühle C*, Schmidtner AK, Gulbins E, Neumann ID, Kornhuber J (2020) Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain. Cells 9. doi: 10.3390/cells9051239

 

2019

  1. Beckervordersandforth R, Rolando C (2019) Untangling human neurogenesis to understand and counteract brain disorders. Curr Opin Pharmacol 50: 67-73. doi: 10.1016/j.coph.2019.12.002
  2. Buchholz VN, Mühle C, Cohort Study on Substance Use Risk Factors, Kornhuber J, Lenz B (2019) Lower Digit Ratio (2D:4D) Indicative of Excess Prenatal Androgen Is Associated With Increased Sociability and Greater Social Capital. Front Behav Neurosci 13: 246. doi: 10.3389/fnbeh.2019.00246
  3. Cantone M*, Küspert M*, Reiprich S*, Lai X, Eberhardt M, Gottle P, Beyer F, Azim K, Küry P, Wegner M, Vera J (2019) A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation. Glia 67: 825-843. doi: 10.1002/glia.23569
  4. Elsesser O, Fröb F, Küspert M, Tamm ER, Fujii T, Fukunaga R, Wegner M (2019) Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system. Nucleic Acids Research 47: 6208-6224. doi: 10.1093/nar/gkz376
  5. Endres D, Rauer S, Kern W, Venhoff N, Maier SJ, Runge K, Süß P, Feige B, Nickel K, Heidt T, Domschke K, Egger K, Pruss H, Meyer PT, Tebartz van Elst L (2019) Psychiatric Presentation of Anti-NMDA Receptor Encephalitis. Front Neurol 10: 1086. doi: 10.3389/fneur.2019.01086
  6. Fiebig C, Keiner S, Ebert B, Schäffner I, Jagasia R, Lie DC, Beckervordersandforth R (2019) Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion. Frontiers in Molecular Neuroscience 12:40. doi: 10.3389/fnmol.2019.00040
  7. Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J (2019) Oligodendroglial alpha-synucleinopathy-driven neuroinflammation in multiple system atrophy. Brain Pathol 29: 380-396. doi: 10.1111/bpa.12678
  8. Kaindl J*, Meiser I*, Majer J*, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B (2019) Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Translational Medicine 8: 247-259. doi: 10.1002/sctm.18-0121
  9. Kaindl J, Winner B (2019) Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci 42: 159-183. doi: 10.1007/7854_2019_111
  10. Kalinichenko LS, Hammad L, Reichel M, Kohl Z, Gulbins E, Kornhuber J, Müller CP (2019) Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain Res Bull 146: 310-319. doi: 10.1016/j.brainresbull.2019.01.026
  11. Kalinichenko LS, Mühle C, Eulenburg V, Praetner M, Reichel M, Gulbins E, Kornhuber J, Müller CP (2019) Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice. Frontiers in Neurology 10:731. doi: 10.3389/fneur.2019.00731
  12. Konrad EDH, Nardini N, Caliebe A, Nagel I, Young D, Horvath G, Santoro SL, Shuss C, Ziegler A, Bonneau D, Kempers M, Pfundt R, Legius E, Bouman A, Stuurman KE, Ounap K, Pajusalu S, Wojcik MH, Vasileiou G, Le Guyader G, Schnelle HM, Berland S, Zonneveld-Huijssoon E, Kersten S, Gupta A, Blackburn PR, Ellingson MS, Ferber MJ, Dhamija R, Klee EW, McEntagart M, Lichtenbelt KD, Kenney A, Vergano SA, Abou Jamra R, Platzer K, Ella Pierpont M, Khattar D, Hopkin RJ, Martin RJ, Jongmans MCJ, Chang VY, Martinez-Agosto JA, Kuismin O, Kurki MI, Pietilainen O, Palotie A, Maarup TJ, Johnson DS, Venborg Pedersen K, Laulund LW, Lynch SA, Blyth M, Prescott K, Canham N, Ibitoye R, Brilstra EH, Shinawi M, Fassi E, Study DDD, Sticht H, Gregor A, Van Esch H, Zweier C (2019) CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum. Genet Med 21: 2723-2733. doi: 10.1038/s41436-019-0585-z
  13. Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stuve O (2019) MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 10:903. doi: 10.3389/fimmu.2019.00903
  14. Lenz B, Köllner MG, Mühle C, Weinland C, Kornhuber J (2019) Basic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmission. J Clin Med 8(12). pii: E2076. doi: 10.3390/jcm8122076
  15. Lenz B, Mühle C, Cohort Study on Substance Use Risk Factors, Kornhuber J (2019) Lower digit ratio (2D:4D) in alcohol dependence: Confirmation and exploratory analysis in a population-based study of young men. Addict Biol: e12815. doi: 10.1111/adb.12815
  16. Lenz B, Röther M, Bouna-Pyrrou P, Mühle C, Tektas OY, Kornhuber J (2019) The androgen model of suicide completion. Prog Neurobiol 172: 84-103. doi: 10.1016/j.pneurobio.2018.06.003
  17. Mühle C, Barry B, Weinland C, Kornhuber J, Lenz B (2019) Estrogen receptor 1 gene variants and estradiol activities in alcohol dependence. Progress in Neuro-Psychopharmacology & Biological Psychiatry 92: 301-307. doi: 10.1016/j.pnpbp.2019.01.008
  18. Mühle C, Bilbao Canalejas RD, Kornhuber J (2019) Sphingomyelin Synthases in Neuropsychiatric Health and Disease. Neurosignals 27: 54-76. doi: 10.33594/000000200
  19. Mühle C, Wagner CJ, Farber K, Richter-Schmidinger T, Gulbins E, Lenz B, Kornhuber J (2019) Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression. J Clin Med 8(6). pii: E846. doi: 10.3390/jcm8060846
  20. Perez-Branguli F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Borstler T, Mishra H, Graf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B (2019) Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet 28: 961-971. doi: 10.1093/hmg/ddy397
  21. Reyes JF, Sackmann C, Hoffmann A, Svenningsson P, Winkler J, Ingelsson M, Hallbeck M (2019) Binding of alpha-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes. Acta Neuropathol 138: 23-47. doi: 10.1007/s00401-019-02007-x
  22. Salar S, Guhathakurta D*, Marx Hofmann L* (2019) Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes. J Neurophysiol 122: 2203-2205. doi: 10.1152/jn.00089.2019
  23. Schneider J, Karpf J, Beckervordersandforth R (2019) Role of Astrocytes in the Neurogenic Niches. Methods Mol Biol 1938: 19-33. doi: 10.1007/978-1-4939-9068-9_2
  24. Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571
  25. Turan S, Börstler T, Kavyanifar A, Loskarn S, Reis A, Winner B, Lie DC (2019) A novel human stem cell model for Coffin-Siris Syndrome like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet pii: ddz089. doi: 10.1093/hmg/ddz089
  26. Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M (2019) Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia 68(5):932-946. doi: 10.1002/glia.23752
  27. Wagner CJ, Musenbichler C, Böhm L, Färber K, Fischer AI, von Nippold F, Winkelmann M, Richter-Schmidinger T, Mühle C, Kornhuber J, Lenz B (2019) LDL cholesterol relates to depression, its severity, and the prospective course. Prog Neuropsychopharmacol Biol Psychiatry 92: 405-411. doi: 10.1016/j.pnpbp.2019.01.010
  28. Weinland C, Mühle C, Kornhuber J, Lenz B (2019) Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 90: 300-307. doi: 10.1016/j.pnpbp.2018.11.019
  29. Weinland C, Mühle C, Kornhuber J, Lenz B (2019) Crossed Eye/Hand Laterality and Left-Eyedness Predict a Positive 24-Month Outcome in Alcohol-Dependent Patients. Alcohol Clin Exp Res 43: 1308-1317. doi: 10.1111/acer.14051
  30. Wihan J, Grosch J, Kalinichenko LS, Müller CP, Winkler J, Kohl Z (2019) Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T alpha-synuclein-expressing mice. Neurobiol Aging 80: 29-37. doi: 10.1016/j.neurobiolaging.2019.03.014
  31. Wittstatt J, Reiprich S, Küspert M (2019) Crazy Little Thing Called Sox-New Insights in Oligodendroglial Sox Protein Function. Int J Mol Sci 20(11). pii: E2713. doi: 10.3390/ijms20112713
  32. Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N (2019) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. Elife 8. pii: e39598. doi: 10.7554/eLife.39598
  33. Zeitler S*, Ye L*, Andreyeva A, Schumacher F, Monti J, Nurnberg B, Nowak G, Kleuser B, Reichel M, Fejtova A, Kornhuber J, Rhein C, Friedland K (2019) Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity. Journal of Neurochemistry 150: 678-690. doi: 10.1111/jnc.14823

 

2018

  1. Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ (2018) Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep 8: 16196. doi: 10.1038/s41598-018-34480-x
  2. Balta EA, Wittmann MT, Jung M, Sock E, Häberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC (2018) Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci 11: 211. doi: 10.3389/fnmol.2018.00211
  3. Bouna-Pyrrou P, Aufleger B, Braun S, Gattnar M, Kallmayer S, Wagner H, Kornhuber J, Mühle C*, Lenz B* (2018) Cross-Sectional and Longitudinal Evaluation of the Social Network Use Disorder and Internet Gaming Disorder Criteria. Frontiers in Psychiatry 9:692. doi: 10.3389/fpsyt.2018.00692
  4. Fliedner A, Zweier C (2018) X-chromosomale Entwicklungsstörungen im weiblichen Geschlecht. medizinische genetik, vol 30. Springer Medizin, pp 334–341
  5. Gegenhuber B, Weinland C, Kornhuber J, Mühle C*, Lenz B* (2018) OPRM1 A118G and serum beta-endorphin interact with sex and digit ratio (2D:4D) to influence risk and course of alcohol dependence. Eur Neuropsychopharmacol 28: 1418-1428. doi: 10.1016/j.euroneuro.2018.09.002
  6. Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA (2018) The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis. Ann Clin Transl Neurol 5: 668-676. doi: 10.1002/acn3.553
  7. Huber SE, Zoicas I, Reichel M, Mühle C, Büttner C, Ekici AB, Eulenburg V, Lenz B*, Kornhuber J*, Müller CP* (2018) Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way. Addict Biol 23: 904-920. doi: 10.1111/adb.12540
  8. Jacob A*, Wüst HM*, Thalhammer JM, Fröb F, Küspert M, Reiprich S, Balta EA, Lie DC, Wegner M, Sock E (2018) The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis. Journal of Neurochemistry 146: 251-268. doi: 10.1111/jnc.14456
  9. Jung M, Häberle BM, Tschaikowsky T, Wittmann MT, Balta EA, Stadler VC, Zweier C, Dörfler A, Gloeckner CJ, Lie DC (2018) Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons. Molecular Autism 9:20. doi: 10.1186/s13229-018-0200-1
  10. Kavyanifar A*, Turan S*, Lie DC (2018) SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res 371: 91-103. doi: 10.1007/s00441-017-2708-7
  11. Kuhbandner K (2018) Uncovering the Role of Sox2 in Oligodendroglia. J Neurosci 38: 4460-4461. doi: 10.1523/JNEUROSCI.0556-18.2018
  12. Lenz B*, Bouna-Pyrrou P*, Mühle C, Kornhuber J (2018) Low digit ratio (2D:4D) and late pubertal onset indicate prenatal hyperandrogenziation in alcohol binge drinking. Prog Neuropsychopharmacol Biol Psychiatry 86: 370-378. doi: 10.1016/j.pnpbp.2018.02.012
  13. Lenz B, Eichler A, Schwenke E, Buchholz VN, Hartwig C, Moll GH, Reich K, Mühle C, Volz B, Titzmann A, Beckmann MW, Heinrich H, Kornhuber J, Fasching PA (2018) Mindfulness-based Stress Reduction in Pregnancy: an App-Based Programme to Improve the Health of Mothers and Children (MINDFUL/PMI Study). Geburtshilfe Frauenheilkd 78: 1283-1291. doi: 10.1055/a-0677-2630
  14. Mühle C, Weinland C, Gulbins E, Lenz B*, Kornhuber J* (2018) Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls. Int J Mol Sci 19(12). pii: E4028. doi: 10.3390/ijms19124028
  15. Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, Rizo T, Kohl Z, Nygren AOH, Arning L, Schule R, Depienne C, Goldberg L, Frahm C, Stevanin G, Durr A, Schols L, Winner B, Beetz C, Reid E (2018) Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. Brain 141: 1286-1299. doi: 10.1093/brain/awy034
  16. Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plotz S, Farrell M, Trautmann U, Kraus C, Ekici AB, Asadollahi R, Regensburger M, Gunther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A (2018) Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep 8: 17201. doi: 10.1038/s41598-018-35506-0
  17. Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B (2018) Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci 12: 914. doi: 10.3389/fnins.2018.00914
  18. Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schutz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B (2018) alpha-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A 115: 7813-7818. doi: 10.1073/pnas.1713129115
  19. Regensburger M, Mielenz D, Winner B (2018) Swiprosin-1/EFhd2 – another piece in the puzzle of tauopathy? Aging (Albany NY) 10: 522-523. doi: 10.18632/aging.101431
  20. Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B (2018) Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis. Stem Cell Reports 10: 347-355. doi: 10.1016/j.stemcr.2017.12.010
  21. Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Xiang W, Masliah E, Winner B (2018) Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Structure & Function 223: 1357-1368. doi: 10.1007/s00429-017-1561-5
  22. Regensburger M, Tenner F, Mobius C, Schramm A (2018) Detection radius of EMG for fasciculations: Empiric study combining ultrasonography and electromyography. Clin Neurophysiol 129: 487-493. doi: 10.1016/j.clinph.2017.10.037
  23. Regensburger M, Weidner N, Kohl Z (2018) Motor neuron diseases. Clinical and genetic differential diagnostics. Nervenarzt 89: 658-665. doi: 10.1007/s00115-018-0524-2
  24. Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Fuchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J (2018) Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation. Front Psychiatry 9: 496. doi: 10.3389/fpsyt.2018.00496
  25. Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC (2018) FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron 99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017
  26. Straub J*, Konrad EDH*, Grüner J, Toutain A, Bok LA, Cho MT, Crawford HP, Dubbs H, Douglas G, Jobling R, Johnson D, Krock B, Mikati MA, Nesbitt A, Nicolai J, Phillips M, Poduri A, Ortiz-Gonzalez XR, Powis Z, Santani A, Smith L, Stegmann APA, Stumpel C, Vreeburg M, Study DDD, Fliedner A, Gregor A, Sticht H, Zweier C (2018) Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. American Journal of Human Genetics 102: 44-57. doi: 10.1016/j.ajhg.2017.11.008
  27. Turnescu T, Arter J, Reiprich S, Tamm ER, Waisman A, Wegner M (2018) Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia 66: 279-294. doi: 10.1002/glia.23242
  28. Weider M*, Starost LJ*, Groll K*, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M (2018)Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications 9(1):899. doi: 10.1038/s41467-018-03871-z
  29. Wittmann MT, Häberle BM (2018) Linking the Neuropsychiatric Disease Gene TCF4 to Neuronal Activity-Dependent Regulatory Networks. Journal of Neuroscience 38: 2653-2655. doi: 10.1523/Jneurosci.3475-17.2018
  30. Wüst HM, Wegner M (2018) Oncogenic insult to the brain: sox proteins rise to the occasion. Translational Cancer Research: S31-S33. doi: 10.21037/tcr.2017.12.19

 

2017

  1. Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Gunther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E (2017) Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol 216: 1337-1355. doi: 10.1083/jcb.201609033
  2. Ardura-Fabregat A, Boddeke E, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzeriat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Loschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y (2017) Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs 31: 1057-1082. doi: 10.1007/s40263-017-0483-3
  3. Beckervordersandforth R (2017) Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis. Brain Plast 3: 73-87. doi: 10.3233/BPL-170044
  4. Beckervordersandforth R (2017) Newborn Neurons in the Aged Hippocampus-Scarce and Slow but Highly Plastic. Cell Rep 21: 1127-1128. doi: 10.1016/j.celrep.2017.10.049
  5. Beckervordersandforth R*, Ebert B*, Schäffner I, Moss J, Fiebig C, Shin J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, Steib K, von Wittgenstein J, Keiner S, Redecker C, Holter SM, Xiang W, Wurst W, Jagasia R, Schinder AF, Ming GL, Toni N, Jessberger S, Song HJ, Lie DC (2017) Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron 93(3):560-573. doi: 10.1016/j.neuron.2017.03.008
  6. Hammer A, Waschbisch A, Knippertz I, Zinser E, Berg J, Jorg S, Kuhbandner K, David C, Pi J, Bayas A, Lee DH, Haghikia A, Gold R, Steinkasserer A, Linker RA (2017) Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells. Front Immunol 8: 1922. doi: 10.3389/fimmu.2017.01922
  7. Kohl Z, Schlachetzki JC, Feldewerth J, Hornauer P, Munch M, Adame A, Riemenschneider MJ, Winkler J, Masliah E (2017) Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plast 2017: 3851262. doi: 10.1155/2017/3851262
  8. Lazarevic V, Fienko S, Andres-Alonso M, Anni D, Ivanova D, Montenegro-Venegas C, Gundelfinger ED, Cousin MA, Fejtova A (2017) Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling. Front Mol Neurosci 10: 221. doi: 10.3389/fnmol.2017.00221
  9. Lenz B, Mühle C, Braun B, Weinland C, Bouna-Pyrrou P, Behrens J, Kubis S, Mikolaiczik K, Muschler MR, Saigali S, Sibach M, Tanovska P, Huber SE, Hoppe U, Eichler A, Heinrich H, Moll GH, Engel A, Goecke TW, Beckmann MW, Fasching PA, Muller CP, Kornhuber J (2017) Prenatal and adult androgen activities in alcohol dependence. Acta Psychiatr Scand 136: 96-107. doi: 10.1111/acps.12725
  10. Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB (2017) Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle Nerve 55: 761-765. doi: 10.1002/mus.25416
  11. Mühle C, Kornhuber J (2017) Assay to measure sphingomyelinase and ceramidase activities efficiently and safely. Journal of Chromatography A 1481: 137-144. doi: 10.1016/j.chroma.2016.12.033
  12. Mühle C, Kreczi J, Rhein C, Richter-Schmidinger T, Alexopoulos P, Doerfler A, Lenz B*, Kornhuber J* (2017) Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults. Brain Struct Funct 222: 881-894. doi: 10.1007/s00429-016-1253-6
  13. Müller CP, Kalinichenko LS, Tiesel J, Witt M, Stockl T, Sprenger E, Fuchser J, Beckmann J, Praetner M, Huber SE, Amato D, Mühle C, Büttner C, Ekici AB, Smaga I, Pomierny-Chamiolo L, Pomierny B, Filip M, Eulenburg V, Gulbins E, Lourdusamy A, Reichel M, Kornhuber J (2017) Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol 133: 463-483. doi: 10.1007/s00401-016-1658-6
  14. Pons-Espinal M, de Luca E, Marzi MJ, Beckervordersandforth R, Armirotti A, Nicassio F, Fabel K, Kempermann G, De Pietri Tonelli D (2017) Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells. Stem Cell Reports 8: 1046-1061. doi: 10.1016/j.stemcr.2017.02.012
  15. Reiprich S*, Cantone M*, Weider M*, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M (2017) Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65: 1089-1102. doi: 10.1002/glia.23146
  16. Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J (2017) Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression. J Affect Disord 209: 10-15. doi: 10.1016/j.jad.2016.09.019
  17. Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M (2017) Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. J Neurochem 140: 245-256. doi: 10.1111/jnc.13908
  18. Weinland C, Braun B, Mühle C, Kornhuber J, Lenz B (2017) Cloninger Type 2 Score and Lesch Typology Predict Hospital Readmission of Female and Male Alcohol-Dependent Inpatients During a 24-Month Follow-Up. Alcohol Clin Exp Res 41: 1760-1767. doi: 10.1111/acer.13468

 

2016

  1. Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA (2016) alpha-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation 13: 201. doi: 10.1186/s12974-016-0694-4
  2. Hoffmann A, Ettle B, Bruno A, Kulinich A, Hoffmann AC, von Wittgenstein J, Winkler J, Xiang W, Schlachetzki JCM (2016)Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochem Biophys Res Commun 479: 881-886. doi: 10.1016/j.bbrc.2016.09.109
  3. Lenz B, Thiem D, Bouna-Pyrrou P, Mühle C, Stoessel C, Betz P, Kornhuber J (2016) Low digit ratio (2D:4D) in male suicide victims. J Neural Transm (Vienna) 123: 1499-1503. doi: 10.1007/s00702-016-1608-4
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* contributed equally