Graduates

Graduates

Congratulations to all our graduates who successfully defended their thesis and completed the programme!

 

Tim Aberle

Graduate Student

Institute of Biochemistry
Dr. Küspert

Project Title: Function of zinc finger protein 276 during CNS myelination and remyelination as part of the oligodendrocyte transcriptional network

Publications:

Aberle T, Piefke S, Hillgärtner S, Tamm ER, Wegner M, Küspert M (2022). Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Nucleic Acids Research
DOI: 10.1093/nar/gkac042

Awards: Luise-Prell-Preis (awarded for Tim’s excellent master thesis at the medical faculty)

Daniela Anni

Graduate student

Department of Psychiatry and Psychotherapy
Prof. Anna Fejtová

Supervisor

Project Title: Physiological regulation of the synaptic plasticity by Aβ and related APP derived fragments

Publications:

Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A (2021) Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation. Cell Mol Life Sci. doi: 10.1007/s00018-021-03835-5.

Zeitler S, Schumacher F, Monti J, Anni D, Guhathakurta D, Kleuser B, Friedland K, Fejtová A*, Kornhuber J*, Rhein C* (2020) Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems Cells. 2020 Nov 18;9(11):2502. doi: 10.3390/cells9112502

Montenegro-Venegas C*, Fienko S*, Anni D*, Pina-Fernández E, Frischknecht R, Fejtova A (2020) Bassoon inhibits proteasome activity via interaction with PSMB4. Cell Mol Life Sci. 2020 Jul 10. doi: 10.1007/s00018-020-03590-z. *contributed equally

Lazarevic V, Fieńko S, Andres-Alonso M, Anni D, Ivanova D, Montenegro-Venegas C, Gundelfinger ED, Cousin MA, Fejtova A (2017) Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling. Front Mol Neurosci. 21;10:221.

Katharina Braun

MD student

Institute of Biochemistry
Prof. Chichung Lie

Project Title: Role of the intellectual disability and schizophrenia associated transcription factor TCF4 in adult neurogenesis of hippocampal dentate gyrus

Publications:

Braun K, Häberle BM, Wittmann MT, Lie CD (2020) Environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. BMC Neurosci. 2020 Nov 23;21(1):50. doi: 10.1186/s12868-020-00602-3.

Jessica Aprato

Graduate student

Institute of Biochemistry
Prof. Michael Wegner

Project Title: Interplay of Sox8 and Sox10 in mature oligodendrocytes

Publications:

González-Alvarado MN, Aprato J, Baumeister M, Lippert M, Ekici AB, Kirchner P, Welz T, Hoffmann A, Winkler J, Wegner M, Haase S, Linker RA (2021) Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation. Glia. 2021 Nov 17. doi: 10.1002/glia.24120.

Aprato J, Sock E, Weider M, Elsesser O, Fröb F, Wegner M (2020) Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development. Nucleic Acids Res 48: 1254-1270. doi: 10.1093/nar/gkz1158

Cerrato V, Parmigiani E, Figueres-Oñate M, Betizeau M, Aprato J, Nanavaty I, Berchialla P, Luzzati F, de’Sperati C, López-Mascaraque L, Buffo A. Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity. PLoS Biol. 2018 Sep 27;16(9):e2005513. doi: 10.1371/journal.pbio.2005513. eCollection 2018 Sep.

Kristina Battis

Department for Molecular Neurology
Prof. Jürgen Winkler

Project Title: Biophysical and biochemical characteristics of human myelin in health and disease

Publications:

Battis K, Florio J B, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller S J, Cobo I, Fixsen B, Kim H Y, Masliah E, Glass C, Schlachetzki J C M, Rissman R, Winkler J, Hoffmann, A. (2022). CSF1R-mediated myeloid cell depletion prolongs lifespan but aggravates distinct motor symptoms in a model of multiple system atrophy. Journal of Neuroscience. 42(40). 7673-7688.

Battis K, Florio J B, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller S J, Cobo I, Fixsen B, Kim H Y, Masliah E, Glass C, Schlachetzki J C M, Rissman R, Winkler J, Hoffmann, A. (2022). CSF1R-mediated myeloid cell depletion prolongs lifespan but aggravates distinct motor symptoms in a model of multiple system atrophy. Journal of Neuroscience. 42(40). 7673-7688.

Reichenwallner A-K, Vurmaz E, Battis K, Handl L, Üstün H, Mach T, Hörnig G, Lipfert J, Richter L. Optical Investigation of Individual Red Blood Cells for Determining Cell Count and Cellular Hemoglobin Concentration in a Microfluidic Channel. Micromachines. 2021; 12(4):358. https://doi.org/10.3390/mi12040358

Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J. Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy. 2019. Brain Pathol. 29(3): 380-396.

Roberto Damián Bilbao Canalejas

Graduate student

Psychiatrische und Psychotherapeutische Klinik
AG Kornhuber

Project Title: The Role of Sphingomyelin Synthase for Sphingolipid-Controlled Autophagy and Antidepressant Treatment

Publications:

Mühle C, Bilbao Canalejas RD, Kornhuber J (2019) Sphingomyelin Synthases in Neuropsychiatric Health and Disease. Neurosignals 27: 54-76. doi: 10.33594/000000200

Razvan-Marius Brazdis

MD student

Department of Stem Cell Biology
AG Winner

Project Title: The impact of α –Synuclein gene duplication on motor adaptor proteins of anterograde mitochondrial transport

Publications:

Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039

Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10.

Anna Brendler

MD student

Department of Stem Cell Biology
Prof. Beate Winner

Project Title: Role of T cell subsets in alpha-synuclein aggregation in Parkinson’s disease

Publications:

Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039

Christian Fiebig

MD student

Institute of Biochemistry
AG Beckervordersandforth

Project Title: The Impact of ageing and neurodegeneration on mitochondrial morphology in hippocampal stem cells

Publications:

Fiebig, C., Keiner, S., Ebert, B., Schaffner, I., Jagasia, R., Lie, D. C. & Beckervordersandforth, R. 2019. Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion. Front Mol Neurosci, 12, 40.

Beckervordersandforth, R., Ebert, B., Schaffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., Friedland, K., Steib, K., Von Wittgenstein, J., Keiner, S., Redecker, C., Holter, S. M., Xiang, W., Wurst, W., Jagasia, R., Schinder, A. F., Ming, G. L., Toni, N., Jessberger, S., Song, H. & Lie, D. C. 2017. Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron, 93, 560-573 e6.

Anna Fliedner

Graduate student

Institute of Human Genetics
PD. Dr. Christiane Zweier

Project Title: Elucidation of the pathogenesis of Borjeson-Forssman-Lehmann syndrome

Publications:

Fliedner A, Gregor A, Ferrazzi F, Ekici AB, Sticht H, Zweier C (2020) Loss of PHF6 leads to aberrant development of human neuron-like cells. Sci Rep 2020 Nov 4;10(1):19030. doi: 10.1038/s41598-020-75999-2.

Fliedner A, Kirchner P, Wiesener A, van de Beek I, Waisfisz Q, van Haelst M, Scott DA, Lalani SR, Rosenfeld JA, Azamian MS, Xia F, Dutra-Clarke M, Martinez-Agosto JA, Lee H, Center UCG, Noh GJ, Lippa N, Alkelai A, Aggarwal V, Agre KE, Gavrilova R, Mirzaa GM, Straussberg R, Cohen R, Horist B, Krishnamurthy V, McWalter K, Juusola J, Davis-Keppen L, Ohden L, van Slegtenhorst M, de Man SA, Ekici AB, Gregor A, van de Laar I, Zweier C (2020) Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing. Am J Hum Genet. doi: 10.1016/j.ajhg.2020.06.019

Straub J, Gregor A, Sauerer T, Fliedner A, Distel L, Suchy C, Ekici AB, Ferrazzi F, Zweier C (2020) Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster. Sci Rep 10: 1204. doi: 10.1038/s41598-020-58182-5

Pöttler M, Fliedner A, Bergmann J, Bui LK, Mühlberger M, Braun C, Graw M, Janko C, Friedrich O, Alexiou C, Lyer S. Magnetic Tissue Engineering of the Vocal Fold Using Superparamagnetic Iron Oxide Nanoparticles. Tissue Eng Part A. 2019 Nov;25(21-22):1470-1477. doi: 10.1089/ten.TEA.2019.0009. Epub 2019 May 2. PMID: 30747035.

Fliedner A, Zweier C. X-chromosomale Entwicklungsstörungen im weiblichen Geschlecht. medgen 2018 · 30:334–341

Straub J, Konrad EDH, Grüner J, Toutain A, Bok LA, Cho MT, Crawford HP, Dubbs H, Douglas G, Jobling R, Johnson D, Krock B, Mikati MA, Nesbitt A, Nicolai J, Phillips M, Poduri A, Ortiz-Gonzalez XR, Powis Z, Santani A, Smith L, Stegmann APA, Stumpel C, Vreeburg M; Deciphering Developmental Disorders Study, Fliedner A, Gregor A, Sticht H, Zweier C. Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. Am J Hum Genet. 2018 Jan 4;102(1):44-57. doi: 10.1016/j.ajhg.2017.11.008.

Pöttler M, Fliedner A, Schreiber E, Janko C, Friedrich RP, Bohr C, Döllinger M, Alexiou C, Dürr S. Impact of Superparamagnetic Iron Oxide Nanoparticles on Vocal Fold Fibroblasts: Cell Behavior and Cellular Iron Kinetics. Nanoscale Res Lett. 2017 Dec;12(1):284. doi: 10.1186/s11671-017-2045-5.

Maria Nazareth Gonzalez Alvarado

Graduate student

Department of Neurology
Prof. Ralf Linker

Project Title: Role of the transcription factors Sox8 and Sox10 in susceptibility and repair in demyelinating diseases

Publications:

González-Alvarado MN, Aprato J, Baumeister M, Lippert M, Ekici AB, Kirchner P, Welz T, Hoffmann A, Winkler J, Wegner M, Haase S, Linker RA (2021) Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation. Glia. 2021 Nov 17. doi: 10.1002/glia.24120.

Karlsson L, González-Alvarado MN, Motalleb R, Wang Y, Wang Y, Börjesson M, Zhu C, Kuhn HG. Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis. Mol Neurobiol. 2020 Nov 16. doi: 10.1007/s12035-020-02189-6. Epub ahead of print. PMID: 33200398.

Gonzalez-Alvarado MN, Rotger C, Berger L, London B, Haase S, Kuhbandner K, Lee DH, Linker RA (2020) Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol 343: 577227. doi: 10.1016/j.jneuroim.2020.577227

Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8

Karlsson L, González-Alvarado MN, Motalleb R, Blomgren K, Börjesson M, Kuhn HG. (2019) Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis. Sci Rep. 2019 Aug 23;9(1):12320. doi: 10.1038/s41598-019-48795-w.

Raselli T, Wyss A, Gonzalez Alvarado MN, Weder B, Mamie C, Spalinger MR, Van Haaften WT, Dijkstra G, Sailer AW, Imenez Silva PH, Wagner CA, Tosevski V, Leibl S, Scharl M, Rogler G, Hausmann M, Misselwitz B. The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis. J Crohns Colitis. 2019 Sep 19;13(9):1186-1200. doi: 10.1093/ecco-jcc/jjz039.

Karlsson L, González-Alvarado MN, Larrosa-Flor M, Osman A, Börjesson M, Blomgren K, Kuhn HG.(2018) Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke. Neuroscience 384:314-328.

Lisa Hassel

Graduate Student

Institute of Biochemistry
Prof. Michael Wegner

Project Title: Sox9 transcription factor as a modulator of disease and cure

Publications:

Vogel JK, Weider M, Engler LA, Hillgärtner S, Schmitt C, Hermans-Borgmeyer I, Wegner M: Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia. 2019 Nov 14. doi: 10.1002/glia.23752.

Jana Heppt

Graduate student

Institute of Biochemistry
Prof. Dieter Chichung Lie

Project Title: Investigating the role of canonical Wnt-signaling in maturation of adult hippocampal Neurons

Publications:

Heppt J, Wittmann MT, Schäffner I, Billmann C, Zhang J, Vogt-Weisenhorn D, Prakash N, Wurst W, Taketo MM, Lie DC (2020) beta-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO J:e104472.doi: 10.15252/embj.2020104472.

Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC. Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci. 2018 Jun 19;11:211. doi: 10.3389/fnmol.2018.00211. eCollection 2018.

Alana Hoffmann

Graduate student

Department for Molecular Neurology
Prof. Jürgen Winkler

Supervisor

Project Title: Immune response and alpha-synuclein: interplay in neurodegeneration and –inflammation

Publications:

Reyes JF, Ekmark-Léwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M (2021) Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease. Acta Neuropathol Commun.;9(1):46. doi: 10.1186/s40478-021-01136-3.

González-Alvarado MN, Aprato J, Baumeister M, Lippert M, Ekici AB, Kirchner P, Welz T, Hoffmann A, Winkler J, Wegner M, Haase S, Linker RA (2021) Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation. Glia. 2021 Nov 17. doi: 10.1002/glia.24120.

Mészáros L, Riemenschneider MJ, Gassner H, Marxreiter F, von Hörsten S, Hoffmann A, Winkler J. Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 2021 Apr 14;9(1):68. doi: 10.1186/s40478-021-01166-x. PMID: 33853667; PMCID: PMC8048356.

Süß P, Rothe T, Hoffmann A, Schlachetzki JCM, Winkler J. The Joint-Brain Axis: Insights From Rheumatoid Arthritis on the Crosstalk Between Chronic Peripheral Inflammation and the Brain. Front Immunol. 2020 Dec 10;11:612104. doi: 10.3389/fimmu.2020.612104. PMID: 33362800; PMCID: PMC7758283.

Mészáros L, Hoffmann A, Wihan J, Winkler J (2020) Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy. Int. J. Mol. Sci., 2020 Apr 16;21(8):2775. doi: 10.3390/ijms21082775.

Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Kronke G, Glass CK, Winkler J, Schlachetzki JCM (2020) Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep 30: 4082-4095 e6. doi: 10.1016/j.celrep.2020.02.109 *equal contribution

Lambrecht V, Hanspach J, Hoffmann A, Seyler L, Mennecke A, Straub S, Marxreiter F, Bäuerle T, Laun FB, Winkler J (2020) Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2020.113314. Accepted 13 April 2020.

Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8

Reyes JF, Sackmann C, Hoffmann A, Svenningsson P, Winkler J, Ingelsson M, Hallbeck M (2019) Binding of alpha-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes. Acta Neuropathol 138: 23-47. doi: 10.1007/s00401-019-02007-x

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stuve O (2019) MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 10:903. doi: 10.3389/fimmu.2019.00903

Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J. Oligodendroglial A-synucleinopathy driven neuroinflammation in multiple system atrophy. Brain Pathol. 2018 Nov 16. doi: 10.1111/bpa.12678.

Hoffmann A, Ettle B, Bruno A, Kulinich A, Hoffmann AC, von Wittgenstein J, Winkler J, Xiang W, Schlachetzki JC. Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochemical and Biophysical Research Communications. 2016. 479(4):881-886. doi: 10.1016/j.bbrc.2016.09.109.

Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA. α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. Journal of Neuroinflammation. 2016. 13(1):201. doi: 10.1186/s12974-016-0694-4. (*contributed equally)

Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs. 2017. 31(12):1057-1082. doi: 10.1007/s40263-017-0483-3.

Marathe HG, Watkins-Chow DE, Wieder M, Hoffmann A, Mehta G, Trivedi A, Aras S, Basuroy T, Mehrotra A, Bennett DC, Wegner M, Pavan WJ, de la Serna IL. BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation. Nucleic Acids Research. 2017. doi: 10.1093/nar/gkx259

Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D. DC subset-specific induction of T cell responses upon antigen uptake via activating or inhibitory Fcγ receptors in vivo. Journal of experimental medicine. 2017. 214(5):1509-1528. doi: 10.1084/jem.20160951.

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Lux A, Eissing N, Baranska A, Lühr J, Hoffmann A, Söder S, Hartmann A, Zenk J, Rogler K, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Geiler S, Repp R, Purbojo A, Cesnjevar R, Ullrich E, Nimmerjahn F, Schultze J, Dudziak D. Identification of transcriptional regulators determining tissue localization of human Dendritic cell subpopulations. Science immunology. 2016. 1 (6), doi: 10.1126/sciimmunol.aai7677

Lehmann CH, Heger L, Heidkamp GF, Baranska A, Lühr JJ, Hoffmann A, Dudziak D. Direct delivery of antigens to dendritic cells via antibodies specific for endocytic receptors as a promising strategy for future therapies. Vaccines. 2016. 4(2), 8; doi:10.3390/vaccines4020008

Heidkamp GF, Lehmann CHK, Heger L, Baranska A, Hoffmann A, Lühr J, D. Dudziak D. Functional Specialization of Dendritic Cell Subsets. Encyclopedia of Cell Biology. 2016. Pages 588-604, Elsevier

Hohoff C, Garibotto V, Elmenhorst D, Baffa A, Kroll T, Hoffmann A, Schwarte K, Zhang W, Arolt V, Deckert D, Bauer A. Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain. Neuropsychopharmacology. 2014. 39(13):2989-99. doi: 10.1038/npp.2014

Johanna Kaindl

Graduate student

Universitätsklinikum Erlangen
Prof. Beate Winner

Project Title: Investigating the inflammatory role of microglia in Parkinson’s disease

Publications:

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571 *contributed equally

Kaindl J, Winner B (2019) Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci 42: 159-183. doi: 10.1007/7854_2019_111

Kaindl J*, Meiser I*, Majer J*, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B. Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Transl Med. 2018 Nov 19. doi: 10.1002/sctm.18-0121. *contributed equally

Atria Kavyanifar

Graduate student

Institute of Biochemistry
Prof. Dieter Chichung Lie

Project Title: Investigating the impact of Sox11 haploinsufficiency on neurodevelopment and disease

Publications:

Boerstler T, Wend H, Krumbiegel M, Kavyanifar A, Reis A, Lie CD, Winner B, Turan S (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome. Stem Cell Res. 2020 Jun 29;47:101889. doi: 10.1016/j.scr.2020.101889.

Turan S, Börstler T, Kavyanifar A, Loskarn S, Reis A, Winner B, Lie DC (2019) A novel human stem cell model for Coffin-Siris Syndrome like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet pii: ddz089. doi: 10.1093/hmg/ddz089

Farrukh A, Zhao S, Paez JI, Kavyanifar A, Salierno M, Cavalié A, Del Campo A. In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV. ACS Appl Mater Interfaces. 2018 Nov 20. doi: 10.1021/acsami.8b15517.

Kavyanifar A*, Turan S*, Lie DC. SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res. 2018 Jan;371(1):91-103. doi: 10.1007/s00441-017-2708-7. Epub 2017 Oct 27. Review. *contributed equally

Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH. Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 2017 Jun 28;8:15922. doi: 10.1038/ncomms15922.

Stefanie Klostermeier

Graduate student

Institute for Medical Physics and Microtissue Engineering & Max-Planck-Zentrum für Physik und Medizin
Prof. Kristian Franze

Project Title: Immunological effects of altered extracellular matrix on Aβ crystallization and immune cell response in Alzheimer´s disease

Publications:

Klostermeier S, Messlinger K, De Col R, Boccaccini A, Distler T, Dietsch R (2020). Alginate dialdehyde-collagen hydrogels and their use in 3D cell culture. WO/2020/245302 http://www.sumobrain.com/patents/WO2020245302A1.html

Enrico Konrad

Graduate student

Institute of Human Genetics
PD Dr. Christiane Zweier

Project Title: Role of chromatin interacting and intellectual disability genes in neurodevelopment

Publications:

Konrad EDH, Nardini N, Caliebe A, Nagel I, Young D, Horvath G, Santoro SL, Shuss C, Ziegler A, Bonneau D, Kempers M, Pfundt R, Legius E, Bouman A, Stuurman KE, Ounap K, Pajusalu S, Wojcik MH, Vasileiou G, Le Guyader G, Schnelle HM, Berland S, Zonneveld-Huijssoon E, Kersten S, Gupta A, Blackburn PR, Ellingson MS, Ferber MJ, Dhamija R, Klee EW, McEntagart M, Lichtenbelt KD, Kenney A, Vergano SA, Abou Jamra R, Platzer K, Ella Pierpont M, Khattar D, Hopkin RJ, Martin RJ, Jongmans MCJ, Chang VY, Martinez-Agosto JA, Kuismin O, Kurki MI, Pietilainen O, Palotie A, Maarup TJ, Johnson DS, Venborg Pedersen K, Laulund LW, Lynch SA, Blyth M, Prescott K, Canham N, Ibitoye R, Brilstra EH, Shinawi M, Fassi E, Study DDD, Sticht H, Gregor A, Van Esch H, Zweier C (2019) CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum. Genet Med 21: 2723-2733. doi: 10.1038/s41436-019-0585-z

Straub J*, Konrad EDH*, Grüner J, Toutain A, Bok LA, Cho MT, Crawford HP, Dubbs H, Douglas G, Jobling R, Johnson D, Krock B, Mikati MA, Nesbitt A, Nicolai J, Phillips M, Poduri A, Ortiz-Gonzalez XR, Powis Z, Santani A, Smith L, Stegmann APA, Stumpel C, Vreeburg M; Deciphering Developmental Disorders Study, Fliedner A, Gregor A, Sticht H, Zweier C. Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. Am J Hum Genet. 2018 Jan 4;102(1):44-57. doi: 10.1016/j.ajhg.2017.11.008. *Equal contribution

Kristina Kuhbandner

Graduate student

Department of Neurology
Prof. Ralf Linker

Supervisor

Project Title: The role of alpha-synuclein during inflammatory demyelination and regeneration in the central nervous system

Awards:

Award for the best talk of a Young Scientific Investigators at ECTRiMS (Congress of the European Committee for Treatment and Research in Multiple Sclerosis). Prize money: 1500 €

Title of the talk: “Mucosal addressin cell adhesion molecule 1 mediated intestinal lymphocyte homing is critical for the development of experimental autoimmune encephalomyelitis”.

Publications:

Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8

Gonzalez-Alvarado MN, Rotger C, Berger L, London B, Haase S, Kuhbandner K, Lee DH, Linker RA (2020) Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol 343: 577227. doi: 10.1016/j.jneuroim.2020.577227

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stüve O. MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019 Apr 26;10:903. doi: 10.3389/fimmu.2019.00903. eCollection 2019.

Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA. The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis. Ann Clin Transl Neurol. 2018 Apr 16;5(6):668-676. doi: 10.1002/acn3.553. eCollection 2018 Jun.

Kuhbandner K. Uncovering the Role of Sox2 in Oligodendroglia. J Neurosci. 2018 May 9;38(19):4460-4461. doi: 10.1523/JNEUROSCI.0556-18.2018.

Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. Review.

Hammer A, Waschbisch A, Knippertz I, Zinser E, Berg J, Jörg S, Kuhbandner K, David C, Pi J, Bayas A, Lee DH, Haghikia A, Gold R, Steinkasserer A, Linker RA. Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells. Front Immunol. 2017 Dec 22;8:1922. doi: 10.3389/fimmu.2017.01922. eCollection 2017.

Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA. α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation. 2016 Aug 26;13(1):201. doi: 10.1186/s12974-016-0694-4.(*contributed equally)

Chih-Hung Lin

Graduate student

Institute of Physiology and Pathophysiology
Prof. Christian Alzheimer/Prof. Johannes Kornhuber

Project Title: Role of the ASM/ceramide system in mediating vulnerability to neuropsychiatric disease

Publications:

Lin CH, Kornhuber J, Zheng F, Alzheimer C. Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability. Front Cell Neurosci. 2021 Apr 9;15:660561. doi: 10.3389/fncel.2021.660561. PMID: 33897374; PMCID: PMC8062921

Lena Marx

Graduate student

Department of Psychiatry and Psychotherapy
Prof. Anna Fejtová

Project Title: Role of activity-dependent CtBP1 shuttling during neurodevelopment and in neurodegeneration

Publications:

Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP (2021) Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. Mol Psychiatry. doi: 10.1038/s41380-021-01304-w

Salar S, Guhathakurta D*, Marx Hofmann L* (2019) Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes. J Neurophysiol 122: 2203-2205. doi: 10.1152/jn.00089.2019

Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Füchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J (2018). Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation. Front Psychiatry. 2018 Oct 16;9:496. doi: 10.3389/fpsyt.2018.00496. eCollection 2018.

Lisa Mészáros

Graduate student

Department for Molecular Neurology
Prof. Jürgen Winkler

Project Title: Impact of molecules on neurotransmitter driven MAPK-mediated signal transduction in oligodendroglial myelination

Publications:

Mészáros L, Riemenschneider MJ, Gassner H, Marxreiter F, von Hörsten S, Hoffmann A, Winkler J. Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 2021 Apr 14;9(1):68. doi: 10.1186/s40478-021-01166-x. PMID: 33853667; PMCID: PMC8048356.

Mészáros L, Hoffmann A, Wihan J, Winkler J (2020) Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy. Int. J. Mol. Sci., 21, 2775; doi:10.3390/ijms21082775. Accepted: 13 April 2020; Published: 16 April 2020

Tatyana Pozner

Graduate student

Department of Stem Cell Biology
Prof. Beate Winner

Project Title: Exploring the cellular and molecular mechanisms of the neurodegenerative phenotype in SPG11

Prices:

Poster Prize at Tom Wahlig annual meeting (March, 2018)

Publications:

Moaraf S, Vistoropsky Y, Pozner T, Heiblum R, Okuliarová M, Zeman M, Barnea A (2020) Artificial light at night affects brain plasticity and melatonin in birds. Neurosci Lett. Jan 18;716:134639. doi: 10.1016/j.neulet.2019.134639.

Güner F, Pozner T, Krach F, Prots I, Loskarn L, Schlötzer-Schrehardt U, Winkler J, Winner B, Regensburger M (2021) Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Front. Neurosci. 15:680572. doi: 10.3389/fnins.2021.680572.

Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. 2020 May 1;awaa099. doi: 10.1093/brain/awaa099. Online ahead of print. *Equal contribution

Cerrone F, Pozner T, Siddiqui A, Ceppi P, Winner B, Rajendiran M, Babu R, Ibrahim HS, Rodriguez BJ, Winkler J, Murphy KJ, O’Connor KE (2020) Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells. Mater Sci Eng C Mater Biol Appl 111: 110832. doi: 10.1016/j.msec.2020.110832

Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B. Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci. 2018 Dec 6;12:914. doi: 10.3389/fnins.2018.00914. eCollection 2018. *Equal contribution

Pérez-Brangulí F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B. Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet. 2018 Nov 22. doi: 10.1093/hmg/ddy397. *Equal contribution

Pozner T, Vistoropsky Y, Moaraf S, Heiblum R, Barnea A. Questioning Seasonality of Neuronal Plasticity in the Adult Avian Brain. Sci Rep. 2018 Jul 26;8(1):11289. doi: 10.1038/s41598-018-29532-1.

Toren A, Pismenyuk T, Yalon M, Freedman S, Simon AJ, Fisher T, Moshe I, Reichardt JK, Constantini S, Mardor Y, Last D, Guez D, Daniels D, Assoulin M, Mehrian-Shai R. Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems. Oncotarget. 2016 Nov 15;7(46):74860-74871. doi: 10.18632/oncotarget.11382.

Mehrian-Shai R, Yalon M, Simon AJ, Eyal E, Pismenyuk T, Moshe I, Constantini S, Toren A. High metallothionein predicts poor survival in glioblastoma multiforme. BMC Med Genomics. 2015 Oct 22;8:68. doi: 10.1186/s12920-015-0137-6.

Neeraja Puliparambil Suresh

Graduate Student

Department of Psychiatry and Psychotherapy
Prof. Fejtová

Project Title: Role of CtBP1-dependant expressional regulation in neurogenic lineage upon antidepressant treatments

Publications:

Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP (2021) Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. Mol Psychiatry. doi: 10.1038/s41380-021-01304-w

Tania Rizo

Graduate student

Department of Stem Cell Biology
Prof. Beate Winner

Supervisor

Project Title: Modelling Endoplasmic Reticulum Pathology in Hereditary Spastic Paraplegia 4 using human iPSC derived Cortical Motor Neurons

Publications:

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571 * equal contribution

Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, Rizo T, Kohl Z, Nygren AOH, Arning L, Schüle R, Depienne C, Goldberg L, Frahm C, Stevanin G, Durr A, Schöls L, Winner B, Beetz C, Reid E. Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. Brain. 2018 May 1;141(5):1286-1299. doi: 10.1093/brain/awy034.

Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Günther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E. Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol. 2017 May 1;216(5):1337-1355. doi: 10.1083/jcb.201609033. Epub 2017 Apr 7.

Johann S, Heitzer M, Kanagaratnam M, Goswami A, Rizo T, Weis J, Troost D, Beyer C. NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients. Glia. 2015 Dec;63(12):2260-73. doi: 10.1002/glia.22891. Epub 2015 Jul 21.

Julia Schneider

Institute of Biochemistry
Dr. Ruth Beckervordersandforth

Project Title: Astrocyte dynamic and astrogliogenesis in the adult murine hippocampus

Publications:

Schneider J, Weigel J, Wittmann MT, Svehla P, Ehrt S, Zheng F, Elmzzahi T, Karpf J, Panagua-Herranz L, Basak O, Ekici A, Reis A, Alzheimer C, Ortega F, Liebscher S, Beckervordersandforth R (2022) Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. The EMBO Journal doi.org/10.15252/embj.2021110409

Schneider J, Karpf J, Beckervordersandforth R (2019) Role of Astrocytes in the Neurogenic Niches. Methods Mol Biol 1938: 19-33. doi: 10.1007/978-1-4939-9068-9_2

Karch S*, Broichhagen J*, Schneider J*, Böning D, Hartmann S, Schmid B, Tripal P, Palmisano R, Alzheimer C, Johnsson K, Huth T. A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00387. *Equal contribution

Eulenburg V, Knop G, Sedmak T, Schuster S, Hauf K, Schneider J, Feigenspan A, Joachimsthaler A, Brandstätter JH. GlyT1 determines the glycinergic phenotype of amacrine cells in the mouse retina. Brain Struct Funct. 2018 Sep;223(7):3251-3266. doi: 10.1007/s00429-018-1684-3.

Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A. Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic Biol Med. 2017 Nov;112:350-359. doi: 10.1016/j.freeradbiomed.2017.08.007.

Lisak DA, Schacht T, Enders V, Habicht J, Kiviluoto S, Schneider J, Henke N, Bultynck G, Methner A. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state. Biochim Biophys Acta. 2015 Sep;1853(9):2104-14. doi: 10.1016/j.bbamcr.2015.03.002.

Katrin Simmnacher

Graduate student

Department of Stem Cell Biology
Prof. Beate Winner

Supervisor

Project Title: Analyzing the role of aging and alpha-synuclein in the neurodegenerative process of Parkinson´s disease

Publications:

Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, Roybon L, Prots I, Xiang W, Winner B. Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17. PMID: 32949572.

Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571

Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10., PMID: 29991596

Judith Stemick

Department for Molecular Neurology
Prof. Jürgen Winkler

Project Title: Fragmentation of Huntingtin in the context of neuronal development and inflammation in a human cellular model of HD

Publications:

Schulze-Krebs A, Canneva F, Stemick J, Plank A-C, Harrer J, Bates GP, Aeschlimann D, Steffan JS, von Hörsten S (2021) Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models. International Journal of Molecular Sciences.  22(16):8914. doi: 10.3390/ijms22168914.

Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J (2020) Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson’s disease. Brain Res 1748:147119. doi: 10.1016/j.brainres.2020.147119.

Regensburger M, Stemick J, Masliah E, Kohl Z, Winner B (2020) Intracellular A53T mutant α-synuclein impairs adult hippocampal newborn neuron integration. Front Cell Dev Biol. 2020 Nov 11;8:561963. doi: 10.3389/fcell.2020.561963. eCollection 2020.

Marxreiter F, Stemick J, Kohl Z (2020) Huntingtin Lowering Strategies. Int J Mol Sci 21(6). pii: E2146. doi: 10.3390/ijms21062146

Kohl Z, Schlachetzki JC, Feldewerth J, Hornauer P, Münch M, Adame A, Riemenschneider MJ, Winkler J, Masliah E. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plast. 2017;2017:3851262. doi: 10.1155/2017/3851262. Epub 2017 Mar 19.

Caroline Swoboda

Psychiatrische und Psychotherapeutische Klinik
AG Kornhuber

Project Title: Identification of biomarkers in depression

Alexander Urbasik

Graduate student

Department of Biology, Animal Physiology
Prof. Johann Helmut Brandstätter

Supervisor

Project Title: Examining the synaptogenesis and synapse maintenance factor Bassoon as a putative factor for the differential sensitivity of photoreceptors to late-onset degeneration.

Publications:

Ryl M, Urbasik A, Gierke K, Babai N, Joachimsthaler A, Feigenspan A, Frischknecht R, Stallwitz N, Fejtová A, Kremers J, von Wittgenstein J, Brandstätter JH (2021) Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes. FASEB J. 35(5):e21520. doi: 10.1096/fj.202001962R.

Jeannette Wihan

Graduate student

Department for Molecular Neurology
Prof. Jürgen Winkler

Project Title: Oligodendrogenesis and myelin homeostasis in multiple system atrophy

Publications:

Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J (2020) Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson’s disease. Brain Res 1748:147119. doi: 10.1016/j.brainres.2020.147119.

Mészáros L, Hoffmann A, Wihan J, Winkler J (2020) Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy. Int. J. Mol. Sci., 21, 2775; doi:10.3390/ijms21082775. Accepted: 13 April 2020; Published: 16 April 2020

Wihan J, Grosch J, Kalinichenko LS, Müller CP, Winkler J, Kohl Z.: Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice. Neurobiol Aging. 2019 Aug;80:29-37. doi: 10.1016/j.neurobiolaging.2019.03.014. Epub 2019 Apr 1.

Marie-Theres Wittmann

Graduate student

Institute of Human Genetics
Prof. André Reis

Project Title: Systems analysis of a neurodevelopmental disease models

Publications:

Wittmann MT, Katada S, Sock E, Kirchner P, Ekici AB, Wegner M, Nakashima K, Lie DC, Reis A (2021) scRNA-Sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development. Development. dev.196022. doi: 10.1242/dev.196022.

Wedel M, Fröb F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M (2020) Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res pii: gkaa218. doi: 10.1093/nar/gkaa218

von Wittgenstein J, Zheng F, Wittmann MT, Balta EA, Ferrazzi F, Schäffner I, Häberle BM, Valero-Aracama MJ, Koehl M, Miranda CJ, Kaspar BK, Ekici AB, Reis A, Abrous DN, Alzheimer C, Lie DC (2020) Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex pii: bhz338. doi: 10.1093/cercor/bhz338

Heppt J, Wittmann MT, Schäffner I, Billmann C, Zhang J, Vogt-Weisenhorn D, Prakash N, Wurst W, Taketo MM, Lie DC (2020) beta-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO J:e104472.doi: 10.15252/embj.2020104472.

Braun K, Häberle BM, Wittmann MT, Lie CD (2020) Environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. BMC Neurosci. 2020 Nov 23;21(1):50. doi: 10.1186/s12868-020-00602-3.

Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ. Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep. 2018 Nov 1;8(1):16196. doi: 10.1038/s41598-018-34480-x.

Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC. Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci. 2018 Jun 19;11:211. doi: 10.3389/fnmol.2018.00211. eCollection 2018.

Jung M, Häberle BM, Tschaikowsky T, Wittmann MT, Balta EA, Stadler VC, Zweier C, Dörfler A, Gloeckner CJ, Lie DC. Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons. Mol Autism. 2018 Mar 22;9:20. doi: 10.1186/s13229-018-0200-1. eCollection 2018.

Wittmann MT, Häberle BM. Linking the Neuropsychiatric Disease Gene TCF4 to Neuronal Activity-Dependent Regulatory Networks. J Neurosci. 2018 Mar 14;38(11):2653-2655. doi: 10.1523/JNEUROSCI.3475-17.2018.

Jan Wittstatt

Graduate student

Institute of Biochemistry
Dr. Simone Reiprich

Supervisor

Project Title: Impact of microRNA on the oligodendroglial gene regulatory network

Publications:

Wittstatt J, Weider M, Wegner M, Reiprich S.: MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture. Glia. 2020 Mar 16. doi: 10.1002/glia.23821. [Epub ahead of print]

Wittstatt J, Reiprich S, Küspert M.: Crazy Little Thing Called Sox-New Insights in Oligodendroglial Sox Protein Function. Int J Mol Sci. 2019 Jun 2;20(11). pii: E2713. doi: 10.3390/ijms20112713. Review.

Reiprich S, Cantone M, Weider M, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M (2017). Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65: 1089-1102.

Hannah Wüst

Graduate student

Institute of Biochemistry
Prof. Michael Wegner

Project Title: The role of histone H2B monoubiquitination in myelinating glia

Publications:

Ittner E, Hartwig AC, Elsesser O, Wüst HM, Fröb F, Wedel M, Schimmel M, Tamm ER, Wegner M, Sock E (2021) SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system. Sci Rep 11,14044. doi: 10.1038/s41598-021-93437-9.

Wüst HM, Wegener A, Fröb F, Hartwig AC, Wegwitz F, Kari V, Schimmel M, Tamm ER, Johnsen SA, Wegner M, Sock E (2020) Egr2-guide histone H2B monoubiquitination is required for peripheral nervous system myelination. Nucleic Acids Res. 2020 Jul 16:gkaa606. doi: 10.1093/nar/gkaa606. Online ahead of print. PMID: 32672815

Jacob A, Wüst HM, Thalhammer JM, Fröb F, Küspert M, Reiprich S, Balta EA, Lie DC, Wegner M, Sock E. The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis. J Neurochem. 2018 Aug;146(3):251-268. doi: 10.1111/jnc.14456. PMID: 29749639

Abe P, Wüst HM, Arnold SJ, van de Pavert SA, Stumm R. CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus. Glia. 2018 Mar 14. doi: 10.1002/glia.23324.

Wüst HM, Wegner M. Oncogenic insult to the brain: sox proteins rise to the occasion. Trans Can Res 2017.doi:10.21037/tcr.2017.12.19

Stefanie Kempf

Graduate student

Department of Psychiatry and Psychotherapy
Prof. Johannes Kornhuber

Supervisor

Project Title: Interaction of the ASM/ceramide system and TRPC6 channels and its role in plasticity and depression like behaviour

Publications:

Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A (2021) Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation. Cell Mol Life Sci. doi: 10.1007/s00018-021-03835-5.

Zeitler S*, Ye L*, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K: Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity. J Neurochem. 2019 Sep;150(6):678-690. doi: 10.1111/jnc.14823. Epub 2019 Aug 22. *equal contribution